Global gene expression as a function of germline genetic variation
نویسندگان
چکیده
منابع مشابه
Global gene expression as a function of germline genetic variation.
Common, functional, germline genetic polymorphisms have been associated with clinical cancer outcomes. Little attention has been paid to the potential phenotypic consequences of germline genetic variation on downstream genes. We determined the germline status of 16 well-characterized functional polymorphisms in 126 children with newly diagnosed acute lymphoblastic leukemia (ALL). We assessed wh...
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Computer-assisted methods have become very important in analyzing biosequence data. However, most of the current methods are limited to nding motifs only. Genes can be regulated in many ways, including combinations of regulatory elements. This research is aimed at combinatorial motif analysis and hypothesis generation. A genome-wide gene expression analysis demonstrated the value of the studies...
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THE RECENT COMPLETION of the human genome sequence has shifted research efforts in genomics toward understanding the function of the human genome, its regulation, and how sequence variation contributes to disease. Large numbers of sequence variants throughout the human genome have been identified, and efforts are currently underway to understand the overall relationship between sequence variati...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2005
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddi170